Malaria Immunity and Drug Resistance

Grant number: 1060785 | Funding period: 2014 - 2016

Completed

Abstract

Resistance to antimalarial drugs is a major global threat for malaria treatment, control and elimination. Assessment of the spread of resistance is severely impeded by the presence of host immunity. This project will identify population biomarkers of immunity during antimalarial treatment to include in studies of antimalarial resistance. These findings will facilitate the correct assessment of the global spread of antimalarial resistance.

Related publications (5)

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Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia

JC Cutts, K O’Flaherty, SG Zaloumis, EA Ashley, JA Chan, MA Onyamboko, C Fanello, AM Dondorp, NP Day, AP Phyo, M Dhorda, M Imwong, RM Fairhurst, P Lim, C Amaratunga, S Pukrittayakamee, TT Hien, Y Htut, M Mayxay, M Abdul Faiz

2022-07-15

Background. Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic effi..

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Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives

K O'Flaherty, R Ataíde, SG Zaloumis, EA Ashley, R Powell, G Feng, L Reiling, AM Dondorp, NP Day, M Dhorda, RM Fairhurst, P Lim, C Amaratunga, S Pukrittayakamee, TT Hien, Y Htut, M Mayxay, MA Faiz, JG Beeson, F Nosten

2019-08-30

Background: Antibodies to the blood stages of malaria parasites enhance parasite clearance and antimalarial efficacy. The antibody..

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Implications of population-level immunity for the emergence of artemisinin-resistant malaria: A mathematical model

N Scott, R Ataide, DP Wilson, M Hellard, RN Price, JA Simpson, FJI Fowkes

2018-08-02

Background: Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low tra..

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Immunity as a predictor of anti-malarial treatment failure: A systematic review

K O'Flaherty, J Maguire, JA Simpson, FJI Fowkes

2017-04-20

Background: Naturally acquired immunity can reduce parasitaemia and potentially influence anti-malarial treatment outcomes; howeve..

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Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort

R Ataide, EA Ashley, R Powell, JA Chan, MJ Malloy, K O'Flaherty, E Takashima, C Langer, T Tsuboi, AM Dondorp, NP Day, M Dhorda, RM Fairhurst, P Lim, C Amaratunga, S Pukrittayakamee, TT Hien, Y Htut, M Mayxay, MA Faiz

2017-03-28

Artemisinin-resistant falciparum malaria, defined by a slow-clearance phenotype and the presence of kelch13 mutants, has emerged i..

University of Melbourne Researchers